Dr. Deborah M. Kurrasch 
BSc, PhD (Purdue University)
Assistant Professor Department of Medical Genetics
Faculty of Medicine
University of Calgary
3330 Hospital Drive NW, Rm 2275
Calgary, AB T2N 4N1
Tel: (403) 210-6713 Fax: (403) 270-0737
Email: kurrasch@ucalgary.ca Lab Website: www.deborahkurrasch.com Research Interests We study hypothalamic programs that underlie neonatal/postnatal neuroendocrine signaling. The transition from a passive fetus to an independent neonate requires activation of a complex network of neuroendocrine genes. To understand what genes are critical during this late developmental time point, and if the postnatal age presents a window of vulnerability for environmental insult, we use the following tools:
· Mice and zebrafish as model organisms
· Immortalized hypothalamic cell line
· Microarray and NextGen Sequencing
· Molecular Biology Techniques
· Targeted Knockdown
· Pharmacological Manipulations
Representative Publications (from 19):
Kurrasch, D.M., Baier, H., Ingraham, H.A. Activity-dependent maintenance of hypothalamic transcriptional programs as revealed by nsf mutant zebrafish. 2009, Neural Development, In Press.
Kurrasch, D.M., Cheung, C.C., Lee, F.V., Tran, P.V., Hata, K., Ingraham, H.A. The Neonatal Ventromedial Hypothalamus Transcriptome Reveals Novel Markers with Spatially Distinct Patterning. J Neurosci., 2007, 27:1
Huang, J., Pashkov, V., Kurrasch, D.M., Wilkie, T.M. Feeding and fasting controls liver expression of a Regulator of G Protein Signaling (Rgs16) in periportal hepatocytes. Comp Hepatol., 2006, 23;5-8.
Kurrasch-Orbaugh, D.M., Parrish, J.C., Watts, V.J., Nichols, D.E. A Complex Signaling Cascade Links the Serotonin2A Receptor to Phospholipase A2 Activation: The Involvement of the MAPK Kinases. J. Neurochemistry, 2003, 980-991.
980-991.
Kurrasch-Orbaugh, D.M., Watts, V.J., Barker, E.L., Nichols, D.E. Serotonin 5-HT2A Receptor-Coupled Phospholipase C and Phospholipase A2 Signaling Pathways Have Different Receptor Reserve. J. Pharmacol. Exp. Ther., 2003, 304, 229-237.
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