Dr. Derrick Rancourt
 Derrick E. Rancourt, Ph.D.
Director, ESTM Facility
Coordinator, MBT Program
Associate Professor
Departments of Oncology and Biochemistry & Molecular Biology
HMRB300, 3330 Hospital Dr. NW
Calgary, AB, Canada, T2N 4N1
Tel: (403) 220-2888 Fax: (403) 283-8727
Email: rancourt@ucalgary.ca
RESEARCH INTERESTS
My lab studies mouse and human preimplantation embryos and the hatching and
invasion process from the perspective serine proteinases and serpins. We
have extensive experience with the derivation, expansion, differentiation
and genetic manipulation of mouse and human embryonic stem cells and have
begun to generate specific tissues for regenerative medicine applications.
PUBLICATIONS
Cormier JT, zur Nieden NI, Rancourt DE and Kallos MS. (2006) Expansion of
Undifferentiated Murine Embryonic Stem Cells as Aggregates in Suspension
Culture Bioreactors. Tissue Eng 12, 3233-3245.
Sharma N, Liu SY, Tang L, Irwin, J, Meng GL, and Rancourt DE. (2006)
Implantation Serine Proteinases (ISP1 & ISP2) Heterodimerize and are
Critical in Murine Embryo Implantation. BMC Dev Biol. 6, 61-73.
Li X-F, Kiedrowski L, Tremblay F, Fernandez FR, Perizzolo M, Winkfein RJ,
Turner RW, Bains J S, Rancourt DE, and Lytton J (2006) Importance of
K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor learning and memory. J.
Biol. Chem. 281,6273.
Meng G, zur Nieden NI, Liu SY, Cormier JT, Kallos MS and Rancourt DE. (2007)
Properties of Murine Embryonic Stem Cells Maintained on Human Foreskin
Fibroblasts without LIF. Mol Reprod Dev Sep 20 [Epub ahead of print].
Woltjen K, Ito K, Tsuzuki, T and Rancourt DE. (2007) Orpheus Recombination:
A Comprehensive Bacteriophage System for Murine Targeting Vector
Construction by Transplacement. Meth Mol Biol 435: 79-94.
zur Nieden NI, Cormier JT, Rancourt DE* and Kallos MS. (2007) Embryonic Stem
Cells Remain Highly Pluripotent Following Long Term Expansion as Aggregates
in Suspension Bioreactors. J Biotechnol 129, 421-32.
zur Nieden NI, Price FD, Davis LA, Everitt RE, and Rancourt DE. (2007) Gene
profiling on mixed ES cell populations reveals a biphasic role for B-catenin
in osteogenic differentiation. Mol Endocrinol 21, 674-85.
Research Funding:
Alberta Cancer Board
· “Can ES Cell Derived Osteoblasts Control Breast Cancer?” 2006-2009
NIH
· “ES Cell Derived Osteoblasts and Chondrocytes for Cytotherapeutic
Application” 2006-2008
CIHR Operating Grant
· “Implantation Serine Proteinases: Structure and Function” 2005-2010
· “Towards Single Embryo Transfer in the Human” 2003-2008
Genome Canada
· “North American Conditional Mouse Mutagenesis Project” 2005-2009
Stem Cell Network
· “Canadian Embryonic Stem Cell Initiative” 2005–2008
· “Cell Therapy of Musculoskeletal Disease” 2005-2008
· “Transcriptional Regulation in ES Cells” 2005-2008
|
 |
|
|
