A MICHEIL INNES
BSc MD FRCPC FCCMG
Associate Professor,
Department of Medical Genetics, Faculty of Medicine, University of Calgary
Clinical Geneticist, Calgary Health Region
Tel: (403) 955-7588 Fax: (403) 955-2701
Research Interests
I am a clinical geneticist with a primary research interest in the clinical and molecular delineation of genetic syndromes. Currently, the conditions I am most interested in are autosomal recessive disorders over-represented in isolated populations including Joubert syndrome, Meckel-Gruber syndrome, Bowen-Conradi syndrome and Bardet-Biedl syndrome. I have been involved in the clinical delineation and mapping of these syndromes. I also have a research interest in CNS malformations, particularly cerebellar hypoplasia and Chiari I malformation.
Publications
Wolf N, Harting I, Innes AM, Patzer S, Zeitler P, Schneider A, Wolff A, Baier K, Zschocke J, Ebinger F, Boltshauser E 2007. Ataxia, delayed dentition and hypomyelination: a novel leukoencephalopathy. Neuropaediatrics. 38(2):64-70.
Orton N, Innes AM, Chudley AE, Bech-Hensen. Unique Disease Heritage of the Dutch-German Mennonite Population. Accepted American Journal of Medical Genetics.
Boycott KM, Parboosingh JS, Scott JN, Mcleod DR, Greenberg CR, Fujiwara TM, Mah JK, Midgley J, Wade A, Bernier FP, Chodirker BN, Bunge M, Innes AM 2007. Meckel Syndrome in the Hutterite Population is actually a Joubert-related Cerebello-Oculo-Renal Syndrome.
Robinson WP, Lauzon JL, Innes AM, Lim K, Arsovska S, McFadden DE 2006. Origin and outcome of pregnancies affected by androgenetic/biparental chimerism. Human Repro. 22:1114-22.
Feuk L, Kalervo A, Lipsanen-Nyman M, Skaug J, Nakabayashi K, Finucane B, Hartung D, Innes M, Kererm B, Nowacyzk MJ, Rivlin J, Roberts W, Senman L, Summers A, Szatmari P, Wong V, Vincent JB, Zeesman S, Osborne LR, Oram Cardy J, Kere J, Scherer SW, Hannula-Jouppi K 2006. Absence of a paternally-inherited FOXP2 gene in Developmental Verbal Dyspraxia. Am J Hum Genet.79: 965-72.
Everman DB, Morgan CT, Lyle R, Laughridge M, Bamshad MJ, Clarkson KB, Colby R, Gurrieri F, Innes AM, Roberson J, Schrander-Stumpel C, van Bokhoven H, Antonarakis SE, Schwartz CE 2006. Frequency of genomic rearrangements involving the SHFM3 locus at chromosome 10q24 in syndromic and non-syndromic split-hand/foot malformation. Am J Med Genet 140A: 1375-83.
Research Funding
Alberta Children’s Hospital Foundation
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“Gene Identification in Human Chiari I Malformations” 2006
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“Characterization and Gene Identification of Novel Neurodevelopment Syndromes in the Hutterite Population of Alberta” 2006
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“Molecular Cytogenic Characterization of Apparently Balanced Chromosomal Rearrangements” 2005-
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“Mapping and identification of genetic cerebellar syndromes in the Hutterite population of Alberta” 2004-2006
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“Characterization of a contiguous Gene Deletion Syndrome Associated with Childhood-Onset Obesity and Learning Difficulties”