Dr. Renée H. Martin
PhD (British Columbia), FCCMG
Professor, Department of Medical Genetics
Adjunct Professor, Department of Biological Sciences
Canada Research Chair in Genetics
3330 Hospital Dr, NW, Calgary, AB, Canada, T2N 4N1
Tel: (403) 220-3018
Fax: (403) 270-2211
Email: rhmartin@ucalgary.ca
website: http://www.fp.ucalgary.ca/reneemartinlab/
Research Interests
Chomosomal and molecular analysis of human sperm in normal men and men at risk of an increased frequency of abnormalities because of their constitution or because of environmental hazards. The use of fluorescence in situ hybridization (FISH), single sperm PCR, and analysis of the synaptonemal complex and meiotic recombination for the study of the etiology of aneuploidy in meiosis and human sperm.
Selected Publications
Sun F, Turek P, Greene C, Ko E, Rademaker A, Martin RH. 2007 Abnormal progression through meiosis in men with nonobstructive azoospermia. Fertility and Sterility 87(3):565-571. Selected for cover illustration.
Ko E, Lowry RB, Martin RH 2007 Analysis of sperm karyotypes in a patient treated with griseofulvin. Archives of Andrology: Journal of Reproductive Systems 53:157-160
Bissonnette F, Cohen J, Collins J, Cowan L, Dale S, Dill S, Greene C, Gysler M, Hanck B, Hughes E, Leader A, McDonald S, Marrin M, Martin RH, Min J, Mortimer D, Mortimer S, Smith J, Tsang B, van Vugt D, Yuzpe A. 2007 Incidence and complications of multiple gestation in Canada: proceedings of an expert meeting. Reproductive BioMedicine Online 14(6):773-790
Sun F, Oliver-Bonet M, Liehr T, Starke H, Ko E, Rademaker A, Martin RH. 2007 Discontinuities and unsynapsed regions in meiotic chromosomes have a trans effect on meiotic recombination of some chromosomes in normal human males. Cytogenetics and Genome Research 119:27-32
Martin RH. 2007 Cytogenetics and male infertility. Proceedings of the 14th World Congress on In Vitro Fertilization and 3rd World Congress on In Vitro Maturation, Medimond S.r.l., eds Tan SL, Gomel V, Gosden R, Tulandi T. p93-99
Oliver-Bonet M, Campillo M, Turek PJ, Ko E, Martin RH. 2007 Analysis of Replication Protein A (RPA) in human spermatogenesis. Molecular Human Reproduction12:837-844. Selected for cover illustration
Tempest HG, Ko E, Chan P, Robaire B, Rademaker A, Martin RH. 2008 Analysis of the chromosome complement of sperm in chemotherapy patients. Human Reproduction 23:251-258
Martin RH. 2008 Meiotic errors in human oogenesis and spermatogenesis. Reproductive BioMedicine Online 16:523-531
Tempest HG, Ko E, Rademaker A, Chan P, Robaire B, Martin RH. 2008 Intra- and inter-individual variations in sperm aneuploidy frequencies in normal men. Fertility and Sterility doi:10.1016/j.fertnstert
Ko E, Martin RH 2008. Immunofluorescence analysis of human spermatocytes. Methods in Molecular Biology, ed Keeney S, Humana Press, Totowa, NJ (in press)
Sun F, Mikhaail-Philips M, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. 2008 The relationship between meiotic recombination in human spermatocytes and aneuploidy in sperm. Human Reproduction doi:10.1093/humrep/den027
Tempest HG, Martin RH. 2008 Meiotic recombination and errors during spermatogenesis. In: Reproductive Endocrinology and Infertility: Clinical and Laboratory Aspects. Eds. CM Peterson and D Carrell, Humana Press (in press)
Martin RH. 2008 Cytogenetic determinants of male infertility. Human Reproduction Update doi:10.1093/humupd/dmn017
Sun F, Mikhaail-PhilipsM, Oliver-Bonet M, Ko E, Rademaker A, Turek P, Martin RH. 2008 Aberrant meiotic recombination is correlated with an increased incidence of sperm aneuploidy in men with nonobstructive azoospermia. Molecular Human Reproduction doi:1093/molehr/gan30
Lian J, Yin Y, Oliver-Bonet M, Liehr T, Starke H, Ko E, Turek P, Sun F, Martin RH. 2008 Variation in crossover interference levels on individual chromosomes from human males. Human Molecular Genetics doi:10.1993/hmg/ddn158
Book Chapter
- Martin RH. 2005 Cytogenetics of human sperm. In Reproductive Medicine, ed. D Wells, Landes Bioscience, Georgetown,Texas http://www.erekah.com/abstract.php?chapid=184&catid=70
- Martin RH. 2005 FISH - Human sperm cells. Encyclopedia of Medical Genomics and Proteomics (eds) Fuchs J, Podda M, Goethe JW, Marcel Decker Inc. New York, NY, pp 478-481
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